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My imagination can quickly spiral into an overwhelming despair.
It was something deeper -- an overwhelming despair about the condition of the world.
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Depression is described as "an alteration in mood ranging from a mild sadness to overwhelming despair.
He knew that he was in a fragile state, but, at the loss of her, he had the brief feeling that he had left his body, a sense of such overwhelming despair that he wanted to obliterate himself from the earth.
(The sink should be white— pastels may cause overwhelming despair— and there should be a mirror behind it).
In a world where life is one of a series of incarnations, there wasn't the overwhelming despair and awkward silence that characterizes Western funerals.
I dreamed I had somehow become the president of Kenya, and this filled me with overwhelming despair.
Sarah and I hugged her, trying, as we have both done all our lives, to protect her from her overwhelming despair.
"We feel overwhelming despair and sorrow, but we know we have to try to somehow cope and continue for Paul," she said.
In his own speech, the Palestinian president, Mahmoud Abbas, took a similar tack, addressing Mr. Bush directly and saying, "We do recognize — and I presume that you share with me this view — that the absence of hope and overwhelming despair would feed extremism".
At the time, I would have insisted that my rituals of self-abuse – drinking, pills, the impulse to put my body in danger in ways I now know were deliberate – were merely efforts to escape; that I was contending, however clumsily, with the overwhelming despair at the absence of God.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com