Rather, they discovered clues were leading to something more subtle – a low-grade, chronic inflammation that has few if any overt symptoms.
However, often a patient with CLL is diagnosed during a routine medical examination that is not conducted because of any overt symptoms of disease (Rozman and Montserrat 1995).
Asymptomatic heart failure is a condition where the heart has undergone some type of structural damage but the individual has yet to develop any overt symptoms of heart failure itself, including shortness of breath upon exertion or excessive fatigue.
Thus, the 0ΔNLS mutation in the ICP0 gene allowed a mild HSV-2 infection to be established in ICR mice that did not produce any overt symptoms of disease following inoculation of the eyes, nose, vagina, or footpads.
In contrast, 14 of 15 mice immunized with HSV-2 0ΔNLS- or MS survived the same, stringent ocular HSV-2 challenge (Fig. S3D), and ∼90% of these mice survived without any overt symptoms of disease for 30 days after challenge.
We recognized, up front, that our characterization of CCD is not without bias; many measures, such as quantifying the colony population, are confounded with the overt symptom of CCD (i.e., lack of adult bee population).
CRC is a silent disease with overt symptoms not usually occurring until an advanced stage [ 8].
A primary consideration is to decide about the nature of dialysis therapy as either a chronic scheduled regimen of therapy or as an "emergent" therapy for overt symptoms attributed to ESRD [ 10, 16, 17].
This model takes the presence of elevated risk, for example as indicated by high blood pressure, to be a disease even in the absence of overt symptoms or a clearly destructive pathological process.
As stated in the results, ICU follow-up was associated with a lower prevalence of more overt symptoms of posttraumatic stress in women 14 months after the ICU stay.
