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Even though, segment (−9 to +36) of the p120ctn promoter has an overall activating effect on the transcription of this gene, deletion of segment (−9 to +36) abolishes the observed difference in the p120ctn promoter activity between malignant (A549) and non-malignant (BEAS-2B) respiratory cells.
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It is currently accepted that killing activity reflects the overall activating and inhibiting signals [1], and thus NKLR/NKLR-Ligand matching will enhance NK stimulating signals in the presence of other inhibitory signals.
This may explain contradictory results in which patients with higher TIMP-2 expression either experienced low cancer recurrence/progression [ 44, 45] or a poor prognosis [ 25, 46- 49], emphasizing the overall activating or inhibitory role of TIMP-2.
Nevertheless, it is clear that not all enzymes of a lipid pathway must be activated to attain an overall lipid activated state [9], [29].
If the nodes situated between the first (third,...) and second (fourth,...) inhibitory edge in the overall activating path already have complementary nodes in the expanded network due to their involvement in other paths, the path will be retained in the expanded network.
Although it was observed that there was less overall activated STAT3 in the infarcted heart, it may still counteract the effects of activated STAT1 and reduce the degree of damage.
Finally, certain subsets of PR-dependent genes (such as those activated by PR-A overall and PR-B) were relatively successful at predicting whether a particular luteal phase sample belonged to the FTEb(S) subgroup (dataset D, total n=12 samples).
Activated CTLs showed an overall higher lytic activity than naïve CTLs.
High ash content can also affect activated carbon; i.e., it reduces the overall activity of the activated carbon.
The network expansion method proposed here has a potential limitation in handling overall activating input-output paths that have inhibitory edges separated by more than one activating edge.
A spectrum of stimulatory signals is likely present in developing gliomas which activate microglial chemotactic responses and promote an overall immunosuppressive microenvironment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com