This KB will be extremely useful for establishing a common reference for assessing the outcomes of computational signal detection methods, and is closely related to the element E.4 described above.
A novel outcome of our computational analysis, which we further validated experimentally, is the prediction of a common negative control mechanism underlying the downregulation of several of the aforementioned cytokines, through ultimate inhibition of the translational factor RPS6 via PI3K/PIP3/PDK1/P70S6K and/or AKT1/TOR signaling obstruction.
The choice for a particular database may, for example, influence the outcome of a computational analysis, as evidenced by diverging results for methods that were applied to multiple metabolic pathway databases [ 19- 22].
A key question to address at this point is whether rotameric states of the amino acid residues, especially the positively charged Lys and Arg implicated in binding, are likely to affect the outcome of the computational study.
Also, and more importantly, an adequate set of secondary assays is available for testing the outcomes of a computational analysis in an experimental setting.
We propose formulations for these problems and report the outcomes of a computational study where we compare the performances of our formulations.
We propose mixed integer programming models for these two problems and report the outcomes of a computational study using the CAB data and the Turkey data.
This can be done through a number of computational tools with the outcomes evaluated in silico using flux balance analysis (FBA) [ 51] and further validated by in vivo experiments.
(The program is a sort of computational competition for a bitcoin reward that is generated roughly every ten minutes).
In addition to being a facilitator of computational work, Gardner is a computational astrophysicist.
Kirchmair et al. provide a comprehensive review of computational approaches for predicting outcomes of xenobiotic transformations [ 24].
