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When we identified more than one publication of an original trial, we assessed these together to maximise data collection.
Thus, we now have an original trial suggesting benefit in both low and high severity risk, with a constant relative risk reduction but variable absolute reduction, and two subsequent trials mimicking the low and high ends of the original trial but failed to repeat the positive findings.
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Blackman, from Taunton, Somerset, was known as Marine A during the original trial process and fully identified after he was found guilty.
26 The public health burden of vitamin A deficiency was further shown by the 30% reduction in mortality among children who received vitamin A in the original trial.
The sample included all resident children (n=47) in the 12-ward substudy area whose mothers were documented to have had night blindness, a clinical symptom of moderate vitamin A deficiency, during the original trial.
The defense team requested that all three be released while awaiting an appearance before the original trial judge.
Ethics approval was from the Northwest Multicentre Research Ethics Committee, as an amendment to the original trial protocol.
Others required a new submission or considered the follow-up protocol an amendment to the original trial protocol.
Others required a new submission or considered the follow-up protocol as an amendment to the original trial protocol.
In our original trial, an increase of 1.6% in liver volume was observed after 6 months, while in another trial liver volume increased with 0.9% after 12 months [ 7, 8].
The type of prenatal care a women obtained in the original trial was not a predictor of the PEDS score (p = 0.737) and was not controlled for in subsequent analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com