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Cellular differentiation progresses through an ordered cascade of events involving cell autonomous and micro-environment regulated expression or activation of transcription factors (TFs).
The process includes an ordered cascade of enzymatic events leading to the production of unique morphological and biochemical features.
Upon infection of permissive cells such as fibroblasts, epithelial cells, endothelial cells, and macrophages, human cytomegalovirus (HCMV) undergoes an ordered cascade of gene expression.
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In this report, we describe the combination of dimerizer-regulated two-hybrid and tetracycline regulatory elements in an ordered cascade, placing expression of endpoint reporters under the control of two distinct drugs.
Bone formation is an intricate and ordered cascade of synthesis of matrix proteins and calcium phosphate in a continuously renewed biological environment and regulated by a cluster of growth factors [ 50].
An infection sets in motion a, normally, well ordered cascade of defence mechanisms to eliminate the pathogen, in which innate and adaptive immune mechanisms cooperate.
In summary, this pilot study demonstrates the feasibility of combining two discrete drug-regulated expression systems in an ordered cascade.
Here we present the analysis of the ordered cascade of the AgMNPV gene expression.
In particular, studies of the 3T3-L1 celineine derived from mouse embryo fibroblasts [ 3] have been valuable for gaining insight into the ordered cascade of molecular events required for adipogenesis [ 4- 6].
A cascade is then an ordered set of consecutive activities of a set of users having follower relations.
Wound healing proceeds in an orchestrated, highly ordered, and overlapping cascade of hemostasis, inflammation, proliferation, and remodeling [ 1, 2] that can be deranged by local or systemic pathologies such as stress [ 3, 4], diabetes [ 5- 9], and infections [ 10- 13], including biofilm infections [ 14, 15], which can result in delayed wound closure and worsened scarring.
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