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In addition to these two reports, a third group, Sacchi's group, has provided an opposite hypothesis, which is that pLG72 could inhibit DAAO activity in cells [ 9].
These observations have led to an opposite hypothesis in which FAD mutations in PSEN cause dementia through a loss of function of γ-secretase, resulting in decreased proteolytic processing of different substrates and compromising intracellular signalling pathways (Shen and Kelleher, 2007; Kelleher and Shen, 2010).
An opposite hypothesis was advanced by Vermeulen et al., who viewed the matrix and its ubiquitous presence as merely coincidental, because stones form by crystallization in urine in the presence of large macromolecules [ 17, 18].
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There were two significant regression coefficients; one was a main effect that was opposite hypothesis 1 (B = .73; P = .02).02
However, the opposite hypothesis in which genes involved in a metabolic pathway would have the tendency to gather during evolution cannot be excluded.
The scientific method requires rigorous testing of a hypothesis (Iraq has weapons of mass destruction) and its opposite hypothesis by systematically weighing all the evidence for and against each hypothesis.
"We were definitely working from the opposite hypothesis," said Dr. Harvey J. Kliman of Yale, the senior author.
The opposite hypothesis — that the state polls are overestimating Mr. Obama's standing — is also a valid one to consider.
The opposite hypothesis, the "common disease, rare variant" idea, "has become increasingly credible," the GlaxoSmithKline team writes.
Fisman and Miguel sought to test the opposite hypothesis: who, in the absence of any legal penalty — the diplomats enjoyed immunity and would never be punished for failure to pay parking tickets — would pay, rather than abuse this prerogative?
In more recent years (late 1980s), actually, the opposite hypothesis has been formulated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com