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"an opposite effect" is correct and usable in written English.
You can use the phrase when you want to describe a result that is the opposite of what was expected or intended. For example, "The medicine was originally intended to reduce the inflammation, but it had an opposite effect and caused the inflammation to worsen."
Exact(60)
The number of effective ancestors appeared to have an opposite effect on dairy versus beef breeds.
"But there can be an opposite effect.
It is possible to envisage an opposite effect.
But now it turns out to have an opposite effect.
Some defense lawyers said a police presence at trials could actually have an opposite effect.
A similar study of mice infected with the flu virus showed an opposite effect.
Which gets me wondering: Is there an opposite effect when Australians check in from overseas?
The evil ones thought they could affect the spirit of America, but it's had an opposite effect.
However, chloride ions have an opposite effect.
A negative body inclination angle causes an opposite effect.
A stricter criterion will lead to an opposite effect.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com