Sentence examples for an ongoing mutation from inspiring English sources

These findings suggest that there may be an ongoing mutation independent of H. pylori infection or clonal selection in the pathogenesis of lymphoma.

The frequency of the sequence heterogeneity in an identical clone varied from 0.25 to 0.49% before eradication of H. pylori and was found to be 0.18% in case 5, with none showing any ongoing mutations as shown in Figure 6.

To determine the sensitivity and precision of our DDiMAP approach, we used the Sanger-level IGH private sequence information from a highly mutated FL case as a biologically relevant mutation pattern in a simulation study incorporating both ongoing mutation from the initial sequence and simulated Illumina HiSeq error patterns in 100 base pair single-ended reads [ 47].

Ongoing mutation provides a substrate on which selection operates, with aberrations yielding increased fitness leading to an increasing proportion of affected cells and their progeny [ 2].

We evaluated its technical performance using synthetic combinations of empirical data as well as simulation data of ongoing mutation in a genetic region with high density of mutation incorporating simulated Illumina HiSeq process errors.

Ongoing mutation, which indicates an intraclonal sequence heterogeneity, shows that lymphoma cells continuously react to antigens in lymphomagenesis (Bakkus et al, 1992; Zelenetz et al, 1992).

Thus, sequencing and analysis methods designed to identify and characterize tumor diversity and evidence of ongoing mutation may provide a relative measure of the mutagenic stress and/or inadequacy of the DNA repair systems within a given tumor with the potential to inform clinical care.

It should be noted that the frequency distribution of detectable variants in this blended dataset is not reflective of an expected distribution for variants arising from ongoing mutation in FL, which would be dominated by lower frequency variants with a VAF <1% [ 31], dependent on the relative rates of mutation to growth.

Additionally it appears that some cells can undergo a limited and atypical form of somatic hypermutation and that measurable levels of AID is still expressed but that ongoing mutation does not appear to be occurring in a number of studied breast cancer cell lines [ 247].

DDiMAP outputs variant patterns with frequencies, enabling rapid phylogenetic analysis of ongoing mutation.

Close linkage to tumor specific mutation patterns is necessary to unambiguously identify low frequency passenger mutations as evidence of ongoing mutation within shifting dominant tumor subclones.