This ongoing multicenter trial is the first prospective, randomized controlled trial in hospitalized patients with LRTI sufficiently powered to show non-inferiority of a PCT guided antibiotic management compared to enforced guidelines.
Analysis of the current results did not enable determination of a critical threshold of increase predicting ROSC with acceptable specificity/sensitivity. Probably, larger patient numbers will be needed and our ongoing multicenter trial (ClinicalTrials.gov NCT01806844) could enable us to analyze whether this critical threshold for rSO2 increase can be determined.
Look AHEAD (Action for Health in Diabetes) is an ongoing multicenter clinical trial examining the effects of weight loss achieved through ILI on cardiovascular events and overall mortality in obese/overweight adults with type 2 diabetes.
The study design, methods, and subject characteristics of Look AHEAD, an ongoing multicenter clinical trial examining whether a behavioral lifestyle intervention targeting weight loss will reduce cardiovascular events and overall mortality in overweight/obese subjects with type 2 diabetes, have been described previously (8).
An ongoing multicenter pilot trial, led by investigators at the Dana-Farber Cancevaluatingthe is evaluating the feasibility and toxicity of 1 year of angiogenesis inhibitor therapy for individuals with less than a pCR after neoadjuvant chemotherapy (see Figure 1).
An ongoing multicenter clinical trial (Advancing Cryptococcal meningitis Treatment in Africa [ACTA] 130) in sub-Saharan Africa hopes to confirm the shortest, simplest effective regimens, but will require backup by universal provision of medicines for routine care.
There is an ongoing, multicenter, international, randomized trial testing the role of eculizumab plus conventional treatment (or conventional treatment alone) that may clarify its utility (NCT00670774) 110.
44 patients that were enrolled in an ongoing multicenter, randomized clinical trial (RCT) involving RSA had a primary THA between December 2001 and October 2005, and a subgroup of 18 patients had a minimum of 5 years of follow-up.
The definite confirmation of efficacy of NovoTTF-100A will be obtained by an ongoing multicenter phase III trial that randomizes over 800 patients with newly diagnosed GBM to undergo standard radiotherapy with concomitant and adjuvant TMZ versus standard radiotherapy plus NovoTTF and adjuvant TMZ treatment.
Currently, there is an ongoing multicenter efficacy and safety trial of exenatide in adolescents with type 2 diabetes.
