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The relative importance of these three obstacles to the evolution of adaptive traits in response to selection is not clear.
The nonlinearity of these phenomena represents a serious obstacle to the prediction of the evolution of the relevant system variables.
In particular, strong UV and X-ray radiations could have been a major obstacle to the formation and evolution of the first biomolecules.
In the 19th century, a major obstacle to the acceptance of natural selection as a general mechanism of evolution was the assumption that inheritance was a blending process.
Successful reproducible secure closure of the transluminal access site represents one of the largest obstacles in the evolution of this discipline.
Given the obstacles hindering in-country and sponsor-related data, we hope that the works of others can contribute to the evolution of this "momentary product" [ 34].
One primary obstacle to the replacement of Gaussian kernels by stable kernels in models of continuous character evolution is that stable distributions have undefined variance [ 17].
However, the evolution of acquired resistance because of a second-site mutation (T790M) within EGFR remains an obstacle to successful treatment.
EP, combined with structural analysis, addresses a major obstacle to efficient drug design: that of appropriate target site selection to limit the evolution of resistance.
If epistasis were the major obstacle to adaptive evolution, the selection would be ineffective from the very beginning of the experiment.
Tells about the evolution of gangdom.
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