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We then mapped the expression data onto the AN networks.
Next, we mapped the differential expression data (DE-set) onto AN networks using the filter experiments tool in MetaCore, which mainly maps the non-root nodes.
Between one and seven differentially expressed "close neighbor" genes were typically located on each of AN networks (see example in See Additional File 3, Supplement Figure S13).
We found that NF- κB is significantly over-connected on the DI and AN networks, showing links to both programs.
Unlike pre-built GG process networks, AN networks are built from input lists of network objects using the manually curated interaction database in MetaCore.
The essential difference between DI and AN networks is that the latter allow non-root objects to form connectors between root nodes.
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