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The phrase "an marked increase" is not correct in written English.
It should be "a marked increase" because "marked" begins with a consonant sound.
Example: "There has been a marked increase in sales this quarter compared to the last."
Alternatives: "a significant increase" or "a noticeable increase."
Exact(1)
Consistent with previous reports (Feuerer et al., 2009; Nishimura et al., 2009; Winer et al., 2009), within the CD3+ gated T cell population there was an marked increase in the proportion of CD8+ T cells and partial decrease in CD4+ T cells in epididymal adipose tissue of HFD-fed WT mice.
Similar(59)
In solvent mixtures, miscibility pressures show a marked increase with increased carbon dioxide content.
The figure would be a marked increase from an earlier projected loss of ¥280 billion.
This has resulted in both a cost savings and a marked increase in quality.
The big difference here from a design perspective is a marked increase in display.
But Amtrak has found that if people use a train, daily service brings a marked increase in riders.
An August report saw a marked increase in the number of people who want to decrease immigration.
Thousands of Taliban have staged an insurgency in the region, with a marked increase in fighting in recent months.
A study at a Digital Equipment Corporation plant in Hudson, Mass., had shown a marked increase in miscarriages among semiconductor workers.
Even a single exposure, they reported, produced a marked increase in the number of eggs that were degenerating.
There was a marked increase in appropriate utterances and a correlated decrease in perseverative ones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com