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The phrase "an issue of substantial concern" is correct and usable in written English.
It can be used when discussing a topic or problem that is significant or important enough to warrant attention or consideration.
Example: "The recent data breach is an issue of substantial concern for our organization, as it affects the privacy of our clients."
Alternatives: "a matter of great importance" or "a significant issue of concern."
Exact(2)
Instead, he used the occasion to downplay the impact of the Greek crisis on the U.S. economy, calling the threat of a Greek default and eurozone departure an "issue of substantial concern," but one that is "primarily of concern to Europe".
These findings indicate that stigmatisation is an issue of substantial concern for people with T2DM, and has harmful consequences.
Similar(58)
These retold tales of how freedom plays (or should play) out further changes what it means to be "personally responsie," traditionally also an issue of substantial religious concern.
"With large numbers of people in close proximity to a major hazard pipeline, our view is that the proposed development raises safety issues of substantial concern.
However, there are a number of substantial concerns about exercise as a treatment option for patients.
Background: The quality of medication use in older adults is a recurring problem of substantial concern.
"She would not have been dismissed had she not spoken out publicly on behalf of 100 Blacks in Law Enforcement on an issue of immediate and substantial concern to the department," Judge Hellerstein wrote.
"This is an issue of grave concern.
These lapses have become an issue of national concern.
Involve an issue of public concern.
It's definitely an issue of growing concern".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com