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It could be an issue of position of Sir4 along the telomere or subtelomere, or an issue of timing in the cell cycle as Sir proteins (individual molecules vs subcomplexes) are recruited to Rap1, etc. 3) Rif1 and Rif2 are clearly important in the story and model, but the experiments here are limited.
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It isn't an issue of positioning a line here and there, but rather a Queen Anne's lace of extraterritorial islands on either side.
"The Republicans are trying to make an issue of my position as chairman of the Democratic Party, trying to tie me into the corruption of the previous administration," Mr. Testa said.
This paper deals with the issue of position tracking control of a high performance hydrostatic actuation system using simple adaptive control.
When he disagreed strongly with congressional policy and decided to make an issue of it, he fortified his position with recognized executive precedent and practice.
"There is no party position on an issue of this gravity," said Representative Martin Frost, Democrat of Texas and party caucus chairman, who supports the resolution.
The senators, Richard J. Durbin of Illinois and Sheldon Whitehouse of Rhode Island, said they wanted to know Mr. Comey's position on "an issue of great importance to our nation: torture".
And he does support the party's position on an issue of the greatest concern to the party and its leader Michael Long -- opposition to what critics of the procedure call partial-birth abortion.
But at its core, this is a pretty striking bit of news: An American president's top adviser admitting that the president deliberately lied to the public about his true position on an issue of significant currency.
Moreover the protocol -- whose name comes from Japan's ancient capital, where its terms were hammered out nearly four years ago after a decade of arduous talks -- represents a rare opportunity for Japan to take the pivotal position on an issue of major international importance.
It's rare that an administration on the cusp of a re-election battle decides to reveal its position on an issue of paramount importance such as Iran, especially when it knows that it's going to suffer a political cost at home.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com