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The phrase "an issue of great" is correct and usable in written English.
It can be used when discussing a topic or concern that is significant or important.
Example: "Climate change is an issue of great concern for future generations."
Alternatives: "a matter of great importance" or "a topic of significant relevance".
Exact(60)
It's an issue of great regret to me.
"That was an issue of great concern," Ms. Metcalf said.
For aeronautical composite structures impact damage is an issue of great concern.
"This case presents an issue of great public concern," she wrote in her decision.
The safety of our chemical plants and refineries is an issue of great importance.
Consequently, desert land preservation within the expanding city limits has become an issue of great concern.
Animal welfare is an issue of great importance in modern food production systems.
The presence of sulfonamides residues in food is an issue of great concern.
The huge demand for energy and construction materials has become an issue of great concern recently.
This is an issue of great concern to China, Froman noted.
"It's a sign of things to come and an issue of great concern," Mr. Regev said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com