Sentence examples for an irreversible modification from inspiring English sources

For example, the formation of carbonyl groups on several amino acid residues is an irreversible modification, and affected proteins are targeted for degradation [47,48].

Altering the conformation of replication complex components may result in an irreversible modification (which is not the case with DAA inhibitors) and thus efficient clearance.

Lactacystin is a Streptomyces lactacystinaeus metabolite that targets the 20S proteasome by an irreversible modification of the amino terminal threonine of β-subunits, while YU102 is a α', β'-epoxyketine, the only peptidyl-glutamylpeptidehydrolyzing (PGPH -specific PGPH -specificn this study [45], [48].

For many years, histone methylation was believed to be an irreversible modification.

These proteins have been shown to mitigate starvation-induced protein carbonylation, which is an irreversible modification associated with senescence [ 35].

Although S-nitrosylation is reversible and tyrosine nitration is considered as an irreversible modification, our results suggest the existence of a putative link between both post-translation modifications.

All acid straw mixtures gave rise to the lower temperature lignin relaxation, as this is a result of the physical glass transition, which occurs below the onset of any irreversible modification of the lignin structure.

However, although reversible labeling of peptides and proteins is of considerable value, there are many circumstances under which a permanent, irreversible modification is required.

One recent report showed that an EGFR inhibitor, CI-1033, inhibits Etk at a sub-micromolar level via irreversible modification of a conserved cysteine residue.

While the enzyme-sensitive disassembly represents a covalent and often irreversible modification of the hydrophilic lipophilic balance, supramolecular disassembly based on noncovalent interactions is a significant challenge.

It is noticed that some strong interactions via electrostatic attraction, an Au-S linkage or/and irreversible modification are still occurring, which leads to structural changes and subsequent time-dependent enzyme inactivation [20].