Sentence examples for an irreversible commitment from inspiring English sources

States of commitment are sometimes described as "specification" to represent a reversible type of commitment and as "determination" to represent an irreversible commitment.

Traversing this checkpoint constitutes an irreversible commitment to cell-cycle progression.

For the latter, a rapid decrease of reduced GSH was observed, which preceded an irreversible commitment to cell death.

Cancer-associated EMT may therefore not represent a complete interconversion of epithelial and mesenchymal phenotypes nor an irreversible commitment to a full-blown mesenchymal state.

Once activated, caspases can often activate other procaspases, allowing initiation of a protease cascade that leads to an irreversible commitment towards cell death.

So in these studies (which include work by Newsome's group and a lovely recent paper from Rushworth's group) there is a commitment being studied, but it is a costly rather than an irreversible commitment.

Thus, MYOGENIN activity constitutes a pivot point for irreversible commitment to terminal differentiation.

Translocation of PS following P2X7 activation cannot therefore be used as a direct measure of irreversible commitment to PCD.

David Cameron has said there will be no second vote on Britain's membership of the EU, as he revealed he will ask European leaders for a "clear, legally binding and irreversible commitment" that Britain will no longer be part of a push for "ever-closer union".

A 24 hr pulse of dox drives irreversible commitment to differentiation in a significant proportion of cells even in the continued presence of LIF + BMP.

To this end, we propose a mathematical model of the intrinsic apoptotic pathway that captures three key dynamical features: a signal threshold to elicit cell death, irreversible commitment to the response, and a time delay that is inversely proportional to signal strength.