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We developed and tested a novel delivery system comprised of (i) an internalizing streptavidin-conjugated monoclonal antibody (mAb-SA) directed against CD22 and (ii) a biotinylated diblock copolymer containing both a positively charged siRNA condensing block and a pH-responsive block to facilitate endosome release.
RESULTS: Girls with depression and anxiety disorders had a significantly greater prevalence of headaches than girls without an internalizing disorder.
The low internalization was also in line with previous studies of CD44v6, which have shown that CD44v6 is commonly not an internalizing receptor [32, 36].
Therefore, we have manufactured ADC by using an internalizing mAbs specific to HM1.24 [ 69].
These scales are further divided into subscales corresponding to an internalizing symptom cluster (e.g., Anxious/Depressed, Withdrawn/Depressed) and an externalizing symptom cluster (Aggressive Behavior and Rule Breaking in the version for 6 12 year-olds, and Aggressive Behavior and attention problems in the version for 1.5-5 year olds).
An internalizing and an externalizing symptom score can be calculated from the corresponding syndrome scales.
Similar(54)
But sometimes learning by rote (a multiplication table, for example) is a useful step towards internalizing a pattern.
This is precisely the situation that would result from a proto-cytoplasmic cell internalizing a nanotube-bound proto-nucleus cell.
Two separate internalizing scores were generated: an internalizing-anxiety score was calculated by summing generalized anxiety and panic disorder symptoms (Cronbach alpha = 0.93), while an internalizing-depression score was generated by summing major depression and dysthymia symptoms (Cronbach alpha = 0.94).
A history of internalizing problems before family bereavement puts an adolescent at a higher risk of internalizing problems in the future.
The results confirm such an association for internalizing and externalizing disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com