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In our experiments, double treatment of glioblastoma spheroids with temozolomide with an intermittent recovery phase of 2 weeks resulted in the complete destruction of U87 spheroids after the second application of the drug, while GaMG cultures continued to grow and attained a fairly high resistance against the drug, albeit under a strong reduction of growth.
"The model is conductance-based and takes advantage of the interplay between a T-type calcium current and a non-specific cation sag current and thus, it is able to generate spindle and delta rhythms". The model also generates intermittent phase locking, non periodic firing, bursts, and tonic spike patterns.
Adaptation is the intermittent phase between phases.
Preoperatively, thirty-two patients had constant phase of intermittent exotropia and one hundred and seventy-one patients had intermittent patients
Intermittent phase coordination is defined as phase recurrence with accuracy α over at least k heartbeats.
If intermittent phase coordination is accompanied by small Δ q values, phase synchronization is not likely or hard to detect.
Intermittent phase coordination was then defined as phase recurrence with accuracy α after m heartbeats over a period of at least k heartbeats following the reference beat.
Intermittent phase coordination between heartbeat and respiration may appear if the two signals occasionally reveal both a reduced variability and a lower order rational frequency ratio.
The proportions of extracellular non-replicating populations increase once regimens 1b and 2a switch from daily to intermittent phase (Additional file 1: Figure S1).
It is hypothesized that RSA pattern class recurrence over at least k heartbeats is strongly related with the intermittent phase coordination defined above.
Both the analysis of bivariate variation and the use of surrogate data suggests that intermittent phase coordination, with k = 3 and α = 0.03, results primarily from central adjustment of heart rate and respiratory rate and not from real beat-to-beat phase synchronization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com