In Figure 1d it is shown that the power of XPEHH and CLR monotonically increases with an exponentially increasing selection coefficient, while |iHS| has highest power with an intermediate (s=0.02) selection coefficient in this research, but the power erodes both with stronger and weaker selection.
Those observations would allow interrupting a running SELEX experiment, skipping some intermediate selection rounds, and instead continuing with a computationally enriched pool at later position, saving time and material expenses.
For example, previous studies indicate that women are positively selected and that men show intermediate selection on observables (Chiquiar and Hanson 2005).
For men, Figure 3 shows a pattern of positive selection in 1990, intermediate selection in 2000 and negative selection in 2010.
For women, Figure 3 shows positive selection in 1990 and 2000 but intermediate selection in 2010.
Most of the Mexican immigrant studies on self-selection patterns have attempted to assess the robustness of Chiquiar and Hanson ( 2005) finding of intermediate selection.
Thus, apparently contradictory conclusions – namely that intermediate selection strength is optimal for rescue versus for eradication – arise from modelling different factors.
In parallel, these exact procedures, that is, the same targeted mating schemes consisting of multiple rounds of shuffling, were carried out using unselected F1 hybrids without intermediate selection for ethanol tolerance.
We carried out two parallel experiments: one in which we performed selection for growth in the presence of ethanol after each round of shuffling and one experiment that started from unselected F1 hybrids and in which no intermediate selection was carried out.
Recessive X-linked disorders represent an intermediate situation where selection occurs primarily through males.
