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Results: The following results are an intermediate analysis of 41 out of 150 patients planned.
An intermediate analysis of toxicity will be realized at least every six months or every 50 patients randomized from the start of patients' recruitment.
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The trial was designed in the expectation of an intermediate analysis when half of the calculated sample size had been achieved; the trial would be interrupted if a difference equal to or greater than 30% determined by ITT was found, if such a difference were statistically significant.
There will be an intermediate analysis after 2 years of follow up.
An intermediate analysis after the enrolment of the first 33 patients was planned, to readjust the population sample size if necessary.
Two intermediate analyses are planned, one for Phase III sample size read justement and the second one to allow for the early identification of the superiority of group B. The first intermediate analysis of survival data will take place at the end of phase II.
The analysis plan includes an intermediate statistical analysis when half of the planned women have been included to ensure there is no significant difference in the adverse events between the two groups.
Furthermore, we present a commuting diagram of intermediate analysis steps, which relates different strategies and enables the reuse of soundness proofs between them.
Finally, in reaction to these normative failures, Habermas seeks to develop an intermediate level of analysis and a new normative conception in the historical analysis of the emergence of the "public sphere" (Öffentlichkeit).
Doctoral dissertation in Information and Computer Science, University of California, Irvine], that an intermediate level of analysis is desirable when applying traditional activity theory in practical human computer interaction and computer supported cooperative work applications, is examined with respect to its teleological and methodological adequacy.
The ANDROMEDA (ANtiarrhythmic trial with DROnedarone in Moderate to severe congestive heart failure Evaluating morbidity DecreAse) study, conducted in patients with recent hospitalization due to severe heart failure (HF), was prematurely stopped because of a higher number of deaths in the dronedarone group at the time of an intermediate safety analysis [ 12].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com