Sentence examples for an interim look from inspiring English sources

Wyeth and its partner in the project, the Elan Corporation, announced last year that they had moved to a Phase 3 study of the product based on an interim look at the results announced on Tuesday.

This Phase II/III trial plans to have a total sample size of 500 patients with an interim look at the completion of Phase II (n = 250), The interim analyses include an assessment of the intervention effect, marker(s) identification and the feasibility study of EMR data as the trial CRF data collection.

Most designs that allow for an interim look are not appropriate for monitoring survival probabilities since many patients will not have enough follow-up by the time of the interim analysis, thus necessitating an inconvenient suspension of accrual while patients are being followed.

A group sequential design with first interim look at N = 235 will ensure both power and efficiency.

However, the actual interim look may be taken at a different sample size, depending on recruitment progress and funding.

An independent data monitoring committee will perform the interim look.

Table 1 shows that if there is a medium effect of music therapy, power at the first interim look (usable N = 235) will be 93%.

The full additivity model had slightly higher gains, but too frequently terminated the trial at the first interim look.

When applying the sequential test in a study with an equivalence hypothesis, calculation of the critical values is complicated by the dependency between the dual test statistics at each interim look.

A critical step in group sequential designs is computation of the appropriate critical values for rejecting H0 at the interim look to keep the overall type I error rate at a prespecified level.

A conservative O'Brien Fleming approach was used, spending rather little α at the interim looks and actual boundary values for each interim look calculated using Proc SEQDESIGN in SAS.