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The fact that these genes can be induced not only by heat shock but also under other stress conditions, as demonstrated in this study, reflects an interconnected mechanism of induction involving the HSFs.
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Disease pathogenesis in amyotrophic lateral sclerosis (ALS) involves a number of interconnected mechanisms all resulting in the rapid deterioration of motor neurons.
Multifactorial diseases such as type 2 diabetes mellitus (T2DM), are driven by a complex network of interconnected mechanisms that translate to a diverse range of complications at the physiological level.
The regulation of sphingolipid metabolism is complex, incompletely understood, and involves a network of multiple interconnected mechanisms [6, 61].
This argues for the generalisable nature of these interconnected mechanisms, and implicates a hierarchy of immune modulators, known to promote the establishment of an immunosuppressive microenvironment [ 2], in the process of IFNγ-driven adaptive immune resistance.
Delineating the relative contribution of these interconnected mechanisms to disease onset is a major challenge.
Targeting these interconnected mechanisms with drugs could treat neurodegenerative diseases like Alzheimer's and Parkinson's, in which deregulated cell death plays a major role, and cancer, in which highly proliferating cells escape death pathways.
The existence of two separate, although interconnected, mechanisms underlying the what- and why- of understanding was confirmed by a behavioral study in humans.
Aging influences the arterial wall through two basic interconnected mechanisms: structural and dynamic.
In mammals, the genome-wide DNA demethylation occurs through several interconnected mechanisms, both passive and active.
Therefore, it is crucial to study disease in light of the full complexity of the underlying network of interconnected mechanisms contributing to pathology [ 1].
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