In his 2009 book, "The Great Reset: How New Ways of Living and Working Drive Post-Crash Prosperity," Richard Florida argues that the modern economy requires a different layout: "The coming decades will likely see more intense clustering of jobs, innovation and productivity in a smaller number of bigger cities and city-regions," he writes.
From that era too came jewels: intense clusters of turquoise and coral at the neckline, especially effective when melding with a Japanese floral print or shown against the pure white of a slim evening dress.
DNA damage acquired in interphase would seem unlikely to exhibit such intense clustering of breaks within such well-circumscribed genomic regions.
One view of cancer clusters holds that the clustering in space and time of cases routinely occurs by chance (Bellec et al. 2006; McNally et al. 2002; Petridou et al. 1996), although investigations such as the EUROCLUS (Clustering of Childhood Leukaemia in Europe) study suggest that isolated intense clusters of childhood leukemia are rare (Alexander 1998).
In striking contrast, ATP induced an intense intracellular clustering of F-actin in macrophage from intermediate state 3 polarization as well as from acute and chronic P2X7R-depleted macrophages, whereas MTX produced essentially the same F-actin pattern as observed in M1 polarized wild-type macrophages.
Nightlife is at its most intense in a cluster of neighbourhoods where pubs, bars and clubs stay open until 3am (some with cover charge, but many offering discounted drinks or two-for-one specials during the 5pm-7pm "houry hour", a Montreal institution), with after-hours clubs catering for the nightlife crowd long after sunrise.
Like a lens, the intense gravity of a cluster of galaxies bends light.
The results indicate that intense clusters are a rare phenomenon that merit careful investigation, although aetiological insights are more likely to come from investigation of large numbers of cases.
In striking contrast, ATP applied to P2X7R-depleted M1 macrophages, or to state 3 intermediate polarized macrophages, produced a rapid and intense intracellular clustering of actin filaments.
The lower image highlights a cluster of intense fires north of the Angara river.
