A single copy gene, with a unique promoter and a relatively small number of regulatory regions, may not sustain this massive and regulated protein expression, whereas multiple copies may achieve an optimal integrated regulation of the LHCII content.
The heterogeneity of the networks (tendency to contain highly connected hubs) was higher in L/D compared to L/L, indicating that L/D conditions lead to a more integrated regulation of metabolism than continuous light.
However, the locus covering gene nodD1nodD2nolA (clone 3 and 4 in EC-IV) as well as a gene bll1843 was induced stronger by SSE than genistein at 12 hpi (Fig. 4B and Table 1), suggesting that higher expression of tts is likely a result of integrated regulation of nodD1nodD2nolA rather than nodW by some compounds in SSE.
62 63 This particular form of cell-cell communication is, in fact, a unique cell/tissue-specific cellular function, with an unquestioned role in integrated regulation of growth, differentiation processes and functions of multicellular organisms and in tissue homoeostatic control.
Such successful experiences would undoubtedly encourage motivation to continue shadowing; or applying Ryan and Deci's (2000) self-determination theory, this falls within integrated regulation (a form of extrinsic motivation that is closest to intrinsic motivation: e.g. willing to do because it is good for improvement).
These results pinpoint to β1 integrin as an interesting target for the integrated regulation of EC response to shear stress.
Quantitative monitoring of such whole network operations by methods of metabolic flux analysis, thus bridges the gap by providing a global perspective of the integrated regulation at the transcriptional, translational and metabolic level.
Both the up- and down-regulation of the p38 MAPK pathway activity by the ROS-mediated regulation of the level of (SH 2Trx-ASK1 complex may represent the mechanism of an integrated simultaneous regulation of multiple genes whose combined levels of activity define the physiological status that confers resistance to oxidative stress and longevity.
In this study, an integrated voltage regulation system including Maximum Power Point Tracking Algorithm (MPPT) is introduced to store and efficient use of the energy produced by renewable sources.
