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This can be due to an insufficient threshold amplification.
PTP1B−/−hepatocytes did not activate the GPx/GR system in response to APAP, probably due to an insufficient threshold to trigger the activation of detoxifying enzymes under these experimental conditions.
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Regions with a circularity above 4 (strong ellipsoidal form) were not included into the calculation of the micelle size, since those objects were attributed to the aggregation of micelles, which the employed image analysis algorithm could not distinguish due to insufficient threshold values in those regions.
Calderini and colleagues [ 8] showed that leaks around the mask led to a prolonged pressurization by the ventilator, in turn leading to an insufficient decrease in V'insp to the cycling threshold.
An explanation for this paradox could be linked to the heterogeneity of the study population involving an insufficient number of patients to reach a significant threshold to observe an effect of inappropriateness.
In the discussion about how thresholds should be derived, the danger of using an insufficient data set has been identified as a basic point [17].
This resulted in an insufficient number of isolated cells (calculated minimum of 2841 cells required; n = 13) or a metabolic activity below threshold (n = 32).
Since this restriction often results in an insufficient model fit, we compared the RSM to an alternative model – the partial credit model (PCM) – which allows the thresholds to vary between items (Wright and Mok [2000]; Wu et al. [2007]).
But incrementalism is an insufficient response.
Simply shedding jobs is an insufficient strategy.
But that proved an insufficient safeguard.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com