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Similar changes in the shape of the epigenetic landscape may also be brought about by external signals - for example endogenous cytokines or environmental chemicals - which by transiently altering the landscape could have an instructive effect on cell fate choice.
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Its main feature is based on one characteristic in application of TRIZ in practical design where different TRIZ tools may have different instructive effects on the problems belonging to different design types.
Recently, Nerlov and colleagues have suggested that high levels of erythropoietin (EPO) may have instructive effects on lineage specification in vivo (Grover et al., 2014), and interestingly Ddit3 has been suggested as a target of EPO signaling in erythro-leukemic cells (Coutts et al., 1999).
As an example of instructive effects of cytokines on transcription factors, IL7 directs commitment of CLP by upregulating expression of EBF [6], [7].
No instructive effect was seen in cells unresponsive to VPA.
Some of the companies are familiar, some aren't, but it's an instructive filter on the market.
Applying complementary approaches, we found that AER/FGF8 plays an instructive role on limb hairy2 regulation.
It is thus highly unlikely that SHH plays an instructive role on hairy2 expression.
While this stigma made life rather difficult for homosexual men, it also had an instructive, not to say repressive, effect on all men.
SHH acts at a long-range and has a long-term permissive effect on hairy2, whereas the FGF effect is of a short-term, short-range instructive nature.
This makes the case of Latvia an instructive laboratory for studying long-term effects of migration in general, and the acquisition to host country citizenship in particular.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com