This result suggests that a high level of HER-2 amplification could be a poor prognostic factor even though it was associated with a good initial sensitivity to trastuzumab.
Small cell lung cancer (SCLC) is an aggressive disease in which, after initial sensitivity to platinum/etoposide chemotherapy, patients frequently relapse with drug-resistant disease.
Initial sensitivity to nicotine constitutes an early predictor of the vulnerability to developing nicotine dependence among novice smokers [ 72– 72].
These findings suggest that a defect in ICL repair may contribute to the initial sensitivity to melphalan and that ICL repair may be an important mechanism by which melphalan acquired resistance emerges in the clinic [ 10, 11].
In general GBC tends to exhibit greater initial sensitivity to chemotherapy but confers a shorter overall survival compared with cholangiocarcinoma (CC)[ 1].
The design approach used an initial sensitivity analysis to identify key products and sections, followed by simulations to test and validate the designs until desired purities for all products are achieved.
Pleasant initial sensitivity to tobacco and number of cigarettes smoked the prior month predicted both outcomes.
Small-cell lung cancers are well known for their initial sensitivity to chemotherapeutic agents.
Despite the initial sensitivity to chemotherapy, several studies have shown that TNBCs carry a poor prognosis [ 11- 13].
In fact, the behaviour of this group of cancers is extremely bad, despite its initial sensitivity to chemotherapy.
