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This information will be used to conduct an initial filtering of candidate InPs and provide the resulting list as input to the selection and binding processes.
We have shown here that, compared to simply ranking the poses output by the docking program according to a single docking score, an initial filtering of the docked poses with a pharmacophore query to remove poses that do not form certain essential interactions with the target binding site greatly improves the quality of the results.
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The model also predicts a general weakening of this initial signal with increasing numbers of inter-chromosomal re-arrangements, as the hypothesis proposes only an initial filter of block duplications, not ongoing direct selection to maintain linkage.
Preliminary analysis indicated phenotype outlier effects causing spurious significant findings due to the lower MAF threshold; after applying an initial filter of association p < 5 × 10 8, we recomputed the chemical × SNP analyses after applying an inverse quantile normalization to EC10.
In such an application the goal is to perform an initial filtering to reduce the amount of files to investigate manually.
From the complete set of markers an initial filtering was performed using SAS® 9.3 [ 85] (script, unpublished), to select those SNPs with Mendelian segregation for 1 1 if segregating only in one parent and 1 2 1 if segregating in both parents.
Initial filtering of probe sets was accomplished by applying an upper and lower threshold of expression (75-20000) of the raw MAS5 values before row and column centering for at least 15 of the 89 arrays.
Our initial filtering of the two VCF files resulted in a compendium of 2,094,954 sites.
Initial filtering of the dipoles occurs in V1, followed by a second filtering stage in V2.
Initial filtering of obtained sequences was performed using quality information.
The exemplary result of initial filtering of the skin lesions is presented in Fig. 3.
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CEO of Professional Science Editing for Scientists @ prosciediting.com