The phrase "an initial disruption of" is correct and usable in written English.
It can be used when discussing the beginning phase of a disturbance or interruption in a process, system, or situation.
Example: "The project faced an initial disruption of operations due to unforeseen circumstances."
Alternatives: "a preliminary interruption of" or "an early disturbance of".
Surprisingly, we find an initial disruption of nucleosomes across the entire gene within 30 s after activation, faster than the rate of Pol II transcription, followed by a second further disruption within 2 min. This initial change occurs independently of Pol II transcription.
First, an initial disruption of the substrate, the so-called "cellulose amorphogenesis" phase, is thought to be mediated at least in part by non-hydrolytic disruptive proteins [ 8].
The lesion consists of an initial disruption of the corneal-conjunctival barrier, characterized by extensive cell proliferation, inflammation and connective tissue remodeling, from the limbus to the central cornea [ 2].
Although an initial disruption of ndhF is a viable hypothesis to explain ndh loss in both Pinus and Welwitschia, the gene disrupting inversions could not be held in common between the gnetophyte and Pinaceae plastomes because, as discussed earlier, none of the inversions can be shared.
Several studies have suggested that primary lesions result from an initial dyschondroplasia associated with an impaired differentiation of chondrocytes [ 22, 33] whereas other studies have supported the hypothesis of an initial disruption of canal blood supply leading to the formation of necrotic cartilage areas [ 34– 34].
To examine whether Ubc9 has one primary function in normal hematopoiesis and probe if all four defects (overgrowth, misdifferentiation, lobe dispersal, and lobe detachment) are triggered from an initial disruption of this primary function, we compared the expression patterns of Dome>GFP, Hml>GFP, and 76B>GFP in developing heterozygous and Ubc9 lymph glands.
Furthermore, this method requires initial disruption of a target gene, and cannot be used in its present form for essential genes.
The idea that bradykinin plays a key role in the initial disruption of the blood brain barrier after ischemia reperfusion was examined by applying it at a high concentration (5 μM) for 10 min.
After the initial disruption of the DGC, disease progression follows a very similar course): (1) membrane permeability followed by mislocalized calcium, nitric oxide, and other signaling moieties, (2) repeated rounds of degeneration and regeneration, (3) inflammation, (4) necrosis, and (5) replacement with myofibroblasts and scar tissue leading to functional decline.
That meant the salamanders were able to overcome the initial disruption of the restoration, which will ultimately improve their habitat.
In all of these presentations, initial disruption of the medial layer of the aorta is the starting point of the vascular wall pathology.
