Polycystic kidney disease, which is the main cystic disease leading to ESRD, is a tubular disease that progresses due to the genetically determined inexorable development and enlargement of cysts that gradually decrease function of the surrounding renal tissue, and this may explain why adjustment for known risk factors did not attenuate the association between cystic kidney disease and ESRD risk.
Unfortunately, they represent only short-lived interventions and temporizing measures which just slow the inexorable development of further deterioration from tissue displacement and brain stem shift [ 2, 3, 23, 24].
Public health discussion once presumed an inexorable parallel between economic development and health transitions, but changes in both technology and disease regimes have challenged this paradigm.
I mean, yes, it probably is having an inexorable affect on our cognitive development and our ability to truly connect with ourselves, let alone approach the complexity of connecting with someone else.
In the real world, as Michael Gordon reported in yesterday's Times, the index that generals use to track developments shows an inexorable slide toward chaos.
The "two-replacements" strategy is becoming an inexorable trend in the world energy development process.
It is unclear whether these minimal amounts of caspase activity are important for development or are simply an inexorable consequence of rapid cell division that is tolerated by the embryo.
This staggering degree of environmental contamination has, predictably, led to an inexorable rise in resistance rates, even as our research and development (R&D) efforts to develop new antibiotics have waned.
While the media discourse on smart grids is certainly in the early stages of development and diffusion, there is something of an inexorable quality about the discourse.
It is an inexorable force.
This resolve is an inexorable one.
