However, the focus of ongoing research has shifted towards genomic variants of phase I and II drug metabolizing enzymes with one important goal being an individual dose adjustment according to a patient's genotype.
However, even with a 4.5-g x 4 dose given by extended 3-h infusions, around one-third of the patients may not achieve a fT > MIC = 100%, which supports the need for an individual dose adjustment using therapeutic drug monitoring [35].
The disposal standards consisted of three components: an individual dose standard, a standard evaluating the impacts of human intrusion into the repository, and a groundwater protection standard.
In two independent experiments, 10/10 of the animals passively immunized with an individual dose of 10 µl immune serum (diluted 1∶10 with sterile saline) survived, while 10/10 untreated control mice died (P: 0.01; Table 4, experiment 1).
At the same time it allowed the calculation of an individual dose reduction for patients with hypertension.
Although the price of an individual dose of vaccine is relatively low the aggregate financial and administrative costs of providing pneumococcal vaccination (and often re-vaccination) to the many subgroups of patients for whom it is currently recommended is substantial.
