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Posterior probabilities of all possible haplotypes for an individual, conditional on the observed genotypes, were estimated using an expectation-maximization (EM) algorithm implemented in the Haplo.Stats package [31], using the default setting for batch size, maximum number of iterations and convergence criteria.
Where exposure series are individual or close to it and outcomes occur only once in an individual conditional Poisson offers little advantage, leaving the conditional logistic case crossover formulation the natural choice.
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Every path (w^{BR_{i}}_{j}) is a set of individual conditional probability fragments p(x|y), representing an edge, i.e., a dependency, from y to x.
Specifically, we wish to predict disease risk for the index individual, conditional on a) their multilocus genotype at V known disease variants, b) their affected sibling's disease state and c) additionally including the affected sibling's multilocus genotype.
Every individual conditional probability fragment from an external shock event is treated in the same noisy-or manner as a dependency towards another node, and thus, multiple shock events can affect one node and one shock event can affect multiple nodes.
As mentioned before, a probabilistic approach is followed, in which every dependency is modeled as an individual local conditional probability.
Such individual conditional probabilities are fragments of a complete CPD and are therefore denoted in lowercase.
Using individual conditional probability fragments leads to a significantly easier design of mission dependency models, as no complete conditional probability distributions need to be designed.
P(D i | G i ) is the product of individual conditional log-likelihoods of observing a base j at site i, (eq. 2). 2 where q j is the error rate converted from the Phred score of the base j.
(From dependencies to distributions) Single dependencies of a random variable Y on X are modeled as individual conditional probability p(x|y) and p(x|¬y).
These means formed the distribution of M under the null hypothesis, reflecting the values of M we could have expected if the direction of the individual conditional differences was random, and was not an effect of the experimental paradigm.
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