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An analysis presented in this paper demonstrates that an independent optimization of the twofold problem dealing both with investment and operation costs does not result in the cheapest solution.
Therefore, minimizing this cost is taken as an independent optimization objective for investors in MIES.
This additive distortion model allows for an independent optimization of the protection levels for each substream, and thus greatly simplifies the task of the runtime optimization.
Each dot describes the result of an independent optimization run.
Here it might be advantageous to use quasi normal modes, because the same few modes could be optimized for a whole range of loss energies, thus, imposing stronger restrictions in comparison to an independent optimization at individual loss energies.
This observation indicates that the optimal cut-off scores for Arabidopsis and non-Arabidopsis datasets may differ and warranted an independent optimization of the tools for the non-Arabidopsis species as well.
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A second, independent optimization procedure is then used to reconstruct each curved stroke in the original sketch, assuming that the curve is planar.
A numerical application of the approach with real data based instances shows significant benefits, when compared to a non-collaborative independent optimization, where the hierarchical levels share no dynamic information and base their decisions on static and independent optimization models.
Secondly, the decomposition method is utilized to simplify the analysis of internal stability and H2 performance index of the whole system to a set of independent optimization problems.
In Figure 6 we show, for the best solutions (cost function under 65) the goodness of fit (F) obtained by each independent optimization run as a function of the number of active variables, i.e. the number of binary variables plus the number of continuous parameters.
The reconstructed pathways and the simulated flux distributions from the TOY model can be found in Additional file 1 and Additional file 2. The simulated results from MicrobesFlux were confirmed by an independent linear optimization of the same TOY model via "linprog" in MATLAB (Additional file 3).
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