In F11 sensory neurons, single-cell Ca2+-imaging experiments revealed that, when compared to menthol, some newly-synthesized compounds were up to 200-fold more potent, though none of them showed an increased efficacy.
Also, unaltered LEAK respiration (oligomycin-induced state 4 respiration) in combination with the detected increased parameters of maximal coupled and uncoupled respiration resulted in higher control ratios, confirming an increased efficacy of the mitochondria from the sepsis patients as compared with controls.
And while any one therapeutic approach is unlikely to give a 100% recovery, combinations of different therapeutic approaches aimed at stabilizing the DGC, for example, exon skipping to partially restore dystrophin expression, combined with tyrosine kinase inhibitors to reduce degradation of dystroglycan, could have an increased efficacy.
However, in 38% of the participating units, liposomal amphotericin B was administered at a daily dose of 5 mg/kg despite clear evidence that doses above 3 mg/kg/day do not have an increased efficacy in the treatment of invasive fungal infections [ 49].
It almost seems to be a paradox that it becomes increasingly difficult to prove an OS effect with increasing efficacy of a new compound.
Delivering afferent bursts of stimulation may be promising as a means of increasing efficacy, but evaluation of potential effects on the heart due to unavoidable efferent stimulation is required.
Tumor-specific targeting using achievements of nanotechnology is a mainstay of increasing efficacy of antitumor drugs.
The model assumes that there is a period of increasing efficacy, where the vaccine confers partial protection until the booster dose is administered.
HA is a promising candidate for increasing efficacy and reducing toxicity of cancer therapies.
This formulation allows injection of a high dose of triamcinolone within a reduced drug volume, thereby increasing efficacy, reducing associated pain and avoiding the need for anaesthetic block.
