The restricted group showed significant reductions (p < 0.05) of several loading parameters as well as an increased side-to-side asymmetry.
In contrast, for the PTG-L and PTG-X based PUEs, crystallinity decreased with an increasing side methyl group content, and the PUEs with PTG-L and PTG-X with highest methyl group content did not crystallize.
A transition away from an interest in BMP2 may be expected due to an increasing side effect profile including postoperative inflammation [ 35, 38] and osteoclast activation [ 39– 41].
Prescribing a drug regime with poorer tolerability may ultimately increase the risk of relapse, as an association between increasing side effects and poorer drug adherence has been shown [ 11].
This lower efficacy could only be overcome by increasing the dose, which in turn could result in an increased risk of side effects.
Intense nHFOV settings with low frequencies and high amplitudes may put infants at an increased risk of side effects due to upper airway desiccation.
High solutions (100 parts per million or above) may carry an increased risk of side effects, including a condition called argyria, in which the skin darkens or turns blue.
In addition, unnecessary use of antibiotics entails an increased risk of side effects [ 3- 5] as well as additional costs [ 6].
In this study, the addition of ribavirin did not improve virologic response rates but led to an increased rate of side effects.
18 Elderly patients have an increased risk of side effects from chemotherapy, due to factors such as decreased organ function, comorbidities, and polypharmacy.
