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One key outcome will be an increased sensitization of the special needs of socially excluded women, an otherwise invisible group.
Changes in joint pathology often result in an increased sensitization of primary sensory neurons and central sensitization, due to the changes in ascending or descending modulatory pathways [ 52].
There are data that depressive episodes are accompanied by an increased sensitization of immune-inflammatory pathways and that the number of depressive episodes is correlated with immune-inflammatory markers such as TNF-α and neopterin [ 10].
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One key outcome we expect is an increased sensitization regarding the existence and special needs of poor marginalized women, primarily through their training.
In other words, the current results indicate that the first two PPT trials may have caused a generalized state of increased sensitization of the nociceptors.
On the other hand, NSAIDs, such as aspirin, salicylate and sulindac sulphide, inhibit the proliferation of cells and induce apoptosis in various cancer cell lines, which is considered an important component of their antitumoural activity, and increased sensitization of cancer cells to anticancer drugs.
Any increased sensitization of the nociceptive receptors could affect the response of the afferent nerve fibers, causing central hyperexcitability of the neurons in the dorsal horn of the spinal cord affecting trigeminal nucleus and facilitating headache symptoms.
Increased sensitization of the nociceptive receptors could affect the response of the afferent nerve fibers, causing central hyperexcitability of the neurons in the dorsal horn of the spinal cord, leading to plastic changes in spinal and/or supraspinal levels.
In parallel to this, the decrease of HIF-1 α stability and, consequentially, of MGMT expression, increased sensitization of cells to TMZ.
ROS production may be one of the mechanisms contributing to increased sensitization of Kupffer cells to LPS in the alcoholic liver (Thakur et al. 2006).
Stress and the subsequent stimulation of inflammation (systemic and local) lead to increased sensitization of pain and further defects of stress response systems (vicious cycle of stress, pain, and inflammation).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com