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Goda and colleagues [ 28] also showed that cells lacking the HIF-1α gene had an increased progression into S phase.
9 14 Recently, an increased progression rate of geographic atrophy (GA) has been recognized during anti-VEGF therapy.
A prospective study in Netherlands confirmed an increased progression of atherosclerosis among smokers lacking the enzyme GSTM1 [ 22].
One of the interesting features of the model is that it allows for an increased progression of metastatic cells to the avascular and the vascular stages immediately after surgery.
Moreover, higher current values of both C1,2C and CS846-epitope and lower more recent values of the CPII/C2C ratio were all marginally associated with an increased progression of radiological damage in the subsequent year.
Reports on various studies, i.e. BOLERO Breast Cancer Trialss of Oral Everolimus), TAMRAD and EFECT, have shown an increased progression free survival (PFS) when Everolimus was combined with aromatase inhibitors [ 53].
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Vemurafenib showed an impressive response rate of 48% compared to 5%, with an increased progression-free survival (5.3 months vs. 1.6 months) (Chapman et al, 2011).
For both fields a continuing rise of publication was found with a tendency to increased progression after the year 1997.
Higher C2C values were associated with a statistically significantly increased progression of radiographic damage during the next year.
SCINIB subjects (5.0%) were more prevalent than AD preclinical stage 3 subjects (3.4%) and showed a trend for increased progression to MCI/DAT.
Because chondrocytes from two of thirteen different human donors responded to IL-1β with robust CHOP expression, it remains to be determined if increased CHOP expression in cartilage is a biomarker for increased progression in evolving OA.
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