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Subjects with an increased objective or subjective sensitivity to cold and any indication of circulatory disturbances or cardiovascular problems were excluded.
There was also a borderline significant trend toward an increased objective RR in patients with grade 3 to 4 immune-related adverse events (4 of 15 [27%] vs 2 of 36 [6%]; P <.05).
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"What we found is that as the extremity of opposition increased, objective knowledge went down, but self-assessed knowledge went up," Fernbach said.
That meta-analysis even questioned whether the "z" hypnotics significantly increased objective total sleep time.
One of those important features is the monotonically increasing objective function in terms of SINR.
However, none of them are very effective for increasing objective sleep or for improving daytime performance.
Similarly, patients with EGFR mutation or FISH-positive tumor samples who received vandetanib had an increased chance of objective tumor response (odds ratios 3.34, CI 0.8 13.89, and 3.90, CI 1.02 14.82, respectively).
A conflict situation appears when several objectives are considered within the optimisation, meaning that an increased performance in one objective may often lead to a decreased performance for the others.
Increasing tumor tissue c-MYC mRNA levels were not significantly associated with an increasing probability of objective response (p = 0.62; hazard ratio 1.04; 95% CI 0.90-1.20).
However, with an increasing number of objectives, calculating the volumes becomes intractable.
On the other hand, the interpretation of Pap smears is subjective, and there is an increasing interest towards more objective molecular tests.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com