Our model suggests an increasing internalization of intentions to do research, with the balance of extrinsic (e.g. Self & Time, Finances, Bureaucracy) and intrinsic (e.g. Competence, Clinical and Personal Relevance) motivations shifting with cumulative clinical and research experience.
MPL-A only slightly increased internalization of Bet v 1, whereas flagellin had no effect on allergen uptake.
As shown (Fig. 6, A and B), GnRH increased internalization of the HA-h.XGnRHR and HA-mGnRHR at 60 min but not at 15 min (data obtained at 0 min were similar to those at 15 min, and data obtained at 30 min were intermediate between the 15 and 60 min data, not shown).
Pertinent to this study, cardiac insulin receptor levels were reduced, most likely as a result of increased internalization of the insulin-insulin receptor complex for degradation, a direct response to the hyperinsulinemia.
Thus, we wondered whether the low HER2 surface levels on CD44highCD24low cells might be due to increased internalization of the receptor, which is a phenomenon known to occur in response to receptor activation.
It is postulated that increased internalization of policies can considerably improve their effectiveness and that suitable institutional arrangements exist to support such increases in internalization.
In the case of [68Ga]- and [177Lu]PSMA-I&T, the increased internalization of [177Lu]PSMA-I&T, which correlates with its improved PSMA affinity compared to [68Ga]PSMA-I&T, was reflected in increased tracer uptake in PSMA-positive tissues in vivo [2].
The mechanisms could in either case be either post-transcriptional, leading to less Ly49 receptors reaching the cell membrane, or increased internalization of some Ly49 receptors.
The addition of NEi reversed the increased internalization of the Δ isp2/ isp3 and partially restored intracellular growth, at 24 h.
