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Most natural mutations in Vpr not only do not disturb the functions of the protein but also potentiate the protein for an increased functionality.
Studies have revealed an age- and androgen-dependent regulation of CRF2 binding in rat intermediate lateral septum, showing an increased functionality from puberty to adulthood [ 36].
In addition, DNA vaccination of soluble PD-1, which interfered with the natural PD-1/PD-L1 interesulted resulted in an increased functionality and antitumor effect in mice [ 35].
According to the findings obtained using curated pathway gene sets, the pathway involved in olfactory signalling and regulation is the least conserved since it has significant features of divergence for three of the parameters considered, indicating an increased functionality in the mouse (Fig. 3, Additional file 5).
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R/qtl [ 22, 23] is a versatile, stand-alone software package with a large number of functions and plotting tools for a wide range of analyses for standard model organism crosses, e.g. F2, backcrosses and intercrosses, and an increasing functionality for the more complex crosses analysed by HAPPY.
Integration of micro- and nanofluidic structures into lab-on-a-chip devices permits increased functionality that is useful for a range of analytical applications.
Since visual functions are assumed to be M-scaled, cortical folding can serve as an anatomical basis for increased functionality on the horizon similar to a retinal specialization known as visual streak, which is found in animals with lower encephalization.
This can be a good thing in terms of increased functionality, but a bad thing in terms of security.
Conventional WCEs have a volume of 2.0 cm; however the increased functionality requires a greater volume to house the mechanisms; therefore a volume of 3.0 cm has been chosen for the microrobot.
To test our hypothesis that caffeine acts as an A2AR inverse agonist under physiological conditions, we generated 6-hydroxydopamine 6-OHDA -lesionedd mice as an animal model for PD, a disease related to A2AR increased functionality.
However, the design of these appendages often involves the need for large, complex and light-weight space structures to achieve increased functionality at a reduced launch cost [5].
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