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Moreover, no patient had a trial of an increased dose of previously effective drugs.
The high and low PG temperatures were reduced linearly with an increased dose while the penetration grew exponentially.
These data are an indication that Auger/conversion electrons do not exacerbate overall renal damage after application with 161Tb-folate as compared to 177Lu-folate, even though they result in an increased dose deposition in the renal tissue.
The results showed that an increased dose of PMSG injection significantly increased the numbers, total diameters, and diameter of each dominant follicle and corpus luteum, as well as serum estradiol and progesterone concentrations (P < 0.05).
Given the study design, the effect of an increased dose of vaccine (30 µg of each antigen) could be assessed and compared to standard dose (15 µg of each antigen) at week 4.
This highlights the potential need for an increased dose, alternate buffer or combination therapy.
The level of protection may be higher with an increased dose.
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Epidemiological studies also found an increased dose-dependent relative risk of cancer in exclusive users of insulin glargine [ 7, 8].
The duration and number of cordless and cellphone calls consistently indicated an increased, dose-dependent risk of suffering from headache.
We recently reported an increased dose-related risk of skin lesions in relation to arsenic exposure in this cohort (Ahsan et al. 2006b).
An increased dose-dependent manner was found for the NSA and RP values of the CTX and CTX/HP-β-CD complex.
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