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This induction coincided with an increase in the expressions of the proapoptotic genes p53 and bax and a drop in the expression of the antiapoptotic gene bcl-2.
Arrested tumour differentiation was linked to the loss of ER and PR hormone receptor expressions and an increase in the expressions of G1 S and G2 M regulators.
FUCAGP levels increased by more than twofold in line with an increase in the expressions of fucosylated tri-antennary glycans (FD numbers 3313, 3312, 3332) and fucosylated tetra-antennary glycans (4424, 4413, 4424 and 4434), along with decreases of 3302, 3303, 4403, or 4404 glycans).
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In contrast, an increase in the expression of CYCA2 4 was detected in transgenic Arabidopsis plants expressing BCTV L2 [ 39].
Hypoxia promoted an increase in the expression of SOX-2, OCT-4, KLF-4, Nanog, Lin-28A and CD133.
CIT1 and IDH1 experienced an increase in the expression level, unlike in the context of the proposed CORE pathway (Fig. 3c).
However, worm elimination induced an increase in the expression of IL-25 as observed both in the pzq-treated and reinfected groups from 5 wppi.
In another report, aspartame-treated animals showed an increase in the expression of apoptotic genes and consequently, enhanced neuronal cell death53.
Moreover, treatment with the dual ERRβ/γ agonist GSK4716 led to an increase in the expression of genes involved in mitochondrial activity56.
In our study, we demonstrated an increase in the expression of FAT/CD36 in obese patients (in VAT and to a lesser extend in SAT) compared to the lean controls.
However, there was an increase in the expression of SOX-2, OCT-4, KLF-4, Nanog, Lin-28A and CD133 in a time-dependent manner after hypoxia treatment in sorted A549 cells (*P<0.05).
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