The phrase "an increase in persistent" is not correct as it is incomplete and lacks a noun to follow "persistent." You can use it in contexts discussing growth or escalation, but it needs to be completed for clarity.
Example: "There has been an increase in persistent issues affecting the project timeline."
Alternatives: "a rise in ongoing" or "an escalation in continual".
SiRNA-mediated knockdown of human tankyrase 1 has been shown to result in cell cycle arrest at mitosis [12], [13], with an increase in persistent sister telomere association [13] and spindle dysfunction [12].
One frequent feature of pathogenic missense mutations is an increase in persistent sodium current that may facilitate premature and sustained firing.
As with the dairy industries there has been an increase in persistent production diseases in the beef industries; namely respiratory diseases and metabolic disorders in the feedlot systems (e.g. Owens et al. 1998; Garcia et al. 2010).
However, a small study of patients with cryptogenic paediatric partial epilepsy revealed a mutation in SCN3A (K354Q) that led to an increase in persistent current and induced epileptiform hyperexcitability in hippocampal neurons (Holland et al., 2008 a ; Estacion et al., 2010).
We previously found that LQT in RTT is related to an increase in persistent Na+ current in cardiomyocytes, and in this work we use a mouse model of RTT to demonstrate that the optimal treatment of LQT and cardiac arrhythmias is chronic Na+ channel blockade.
The long-term effect of infliximab at 1 year was recently described in a small population of patients with RA (n = 26) [ 9], manifesting as a persistent increase in osteocalcin (reflecting bone formation) and a persistent decrease in CTX-I (reflecting bone resorption).
Depending on the specific local parameters (i.e. the connectivity between populations), the effect can be a net increase in persistent activity, a decrease, or elimination of such activity to a non-responsive pattern.
SIDu had a transitory increase in transient AKI but a sustained increase in persistent AKI.
The SCN8A mutation N1768D is a gain-of-function mutation that causes a large increase in persistent sodium current leading to neuronal hyperexcitability (9).
Failure of decolonization therapy in MRSA carriers has been observed by Lee et al. [ 41] who found a significant increase in persistent MRSA carriage in patients with a combined low-level mupirocin and genotypic chlorhexidine resistance.
After 24 h recovery, we observed a significant increase in persistent rods after huntingtin knockdown; 3.5 ± 0.38% of rods persisted in cells transfected with scrambled siRNA versus 21.4 ± 6.5% when huntingtin siRNA was transfected (Fig. 3C).
