The phrase "an increase in overload" is correct and usable in written English.
It can be used in contexts discussing a rise in excessive burden or strain, often in relation to work, systems, or processes.
Example: "The recent changes in the project have led to an increase in overload for the team, making it difficult to meet deadlines."
Alternatives: "a rise in burden" or "an escalation in strain."
Potential reasons might be due to an increase in iron overload in the spleen and upregulation of TNF- α, IL-1, and IL-6.
Deferiprone could cause diarrhea and gastrointestinal effects, arthropathy, increased levels of serum liver enzymes, and progression of hepatic fibrosis associated with an increase in iron overload or hepatitis C. The most serious adverse effects are agranulocytosis and neutropenia; weekly monitoring of the neutrophil count is recommended [ 1].
An increase in calcium overload due to excitotoxicity and increased ROS production during seizures predisposing neurons to degeneration [ 101 – 103 ].
Such an increase in cytoplasmic Ca2+ overload during ischemia-reperfusion in diabetic hearts was markedly reduced in the presence of the NHE inhibitor cariporide.
The increase in transaminases is usually linked to an insufficient dose of deferasirox and an increase in the hepatic iron overload.
Type B natriuretic peptide and its N-terminal fragment (NT-proBNP) are secreted in response to an increase in blood pressure and volume overload.
The fact that protein expression of the collagenases MMP-1 and MMP-13 was accompanied by elevated TIMP-1 levels is compatible with results in chronic pressure- overload induced hypertrophy but contrasts to models with acute pressure-overload showing an increase in MMP activity [ 22]. β1TG mice developed dilatation and heart failure at the age of 12 months [ 11].
Furthermore, researchers reported that muscle mass and strength decreased with aging [ 25], and overload induced an increase in matrix metalloproteinases-2 activity which caused skeletal muscle hypertrophy [ 26].
In addition to intracellular p40Metcalpain, calcium overload induces an increase in two other Met fragments: Met-NTF (in conditioned medium) and the labile Met-CTF, both known to be generated by PS-RIP.
Additionally, several studies in multiple animal models have observed an increase in MT network density during pressure overload induced by aortic banding (Collins et al., 1996; Ishibashi et al., 1996; Tagawa et al., 1998; Wang et al., 1999; Koide et al., 2000).
