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Appearing on Chuck Todd's MSNBC show on the first anniversary of Osama bin Laden's death this May, and asked about the Obama's administration's recent revelations of its drone use protocols, Senor declared that he was "uneasy" with "an incomplete release of information," which he claimed "shapes a political narrative".
We previously showed that DOX-LNA and PEG-hyd-DOX have better antitumor activity than did unconjugated DOX in vitro and in vivo; although administration of PEG-ami-DOX increased the intracellular DOX concentration, its in vitro antitumor efficacy was much poorer owing to an incomplete release of free DOX after cellular uptake and organellar release.
An incomplete release of encapsulated BSA from the gels was observed in all cases.
An incomplete release was measured by ELISA, possibly linked to the rapid concentration decrease of the protein in solution.
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However, the impermeability of the PMMA to the antibiotic(s) to a large extent results in a slow and incomplete release of the antibiotic(s) and, sometimes, failure to reach minimal antibiotic concentration [ 6, 8].
However, an ALBC has its share of shortcomings, one of which is low effectiveness against microbial species, a consequence of incomplete release of the antibiotics [ 6– 8].
Initial in vitro studies of these formulations showed an incomplete gradual release (after 15 days 40% rhGH released from F1 and 60% from F2) and in vivo the best results were obtained with F1.
Higher concentrations of sodium bicarbonate (F numbers 17 and 18) reduced drug release to a level sufficient for incomplete release after the 24-hour period.
This being an alpha (i.e. incomplete) release, Introversion has been able to update the game based on feedback.
On the other hand, particles based on PLGA-capped showed a much slower release and exhibited incomplete release, accompanied by the presence of an insoluble residue remaining even after 180 days.
Compared with the other BH3-only reagents, the BidBad chimera and Bad peptide caused a more graded and often incomplete release of cytochrome c, particularly in the Bax experiments.
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