Most of these proteins circulate in the blood and other body fluids in an inactive form.
Those with an inactive form of the protein have low cholesterol and a low risk of heart attacks.
The majority of our vitamin D is produced when UV rays penetrate the skin and activate an inactive form of the vitamin.
Post-translationally, certain proteins (e.g., insulin) are synthesized in an inactive form and must be chemically modified to become active.
Furthermore, the X-ray crystal structure demonstrated that these compounds stabilize an inactive form of the enzyme.
In addition, it provides a rationale for the future design of potent inhibitors with drug-like properties targeting an inactive form of the enzyme.
Vibriolysin is expressed as an inactive form in E. coli possibly due to the inhibitory effect of the N-terminal propeptide.
Heme proteins with an imidazole ligand such as myoglobin and hemoglobin as well as an inactive form of P450 are characterized by Soret maxima at 420 nm [7].
Thus, YfiB alone represents an inactive form that may only partially insert into the PG matrix.
In the protein switch strategy, however, a doctor would instead administer a "prodrug," meaning an inactive form of a cancer-fighting drug.
MMPs are synthesized in an inactive form, which could be activated after removing the pro-peptide domain (Pei et al., 2000).
