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It occurs mainly in an inactive bound form in most body tissues.
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Rho GTPases cycle between an active GTP bound and an inactive GDP bound state.
Rap1 is a member of the family of Ras-like small G proteins [ 28]; accordingly, it switches between an active conformation bound to the GTP and an inactive one bound to the GDP.
Small GTPases act as molecular switches that cycle between an inactive GDP bound form and an active GTP bound form.
However, in all of these organisms, the relative importance of EF-Ts is to function in recycling of EF-Tu from an inactive GDP bound state to an active GTP bound state.
In muscle tissue most, but not all, of the CAPN3 protein can be found in an inactive form bound to the sarcomere.
CREB3 subfamily transcription factors exist ambiently in an inactive form bound to the ER membrane.
Under unstimulated conditions, NF- κB is an inactive complex bound to I κBα in cytosol.
When phosphorylated by Akt, it is localized in the cytosol as an inactive complex bound with 14-3-3 14-3-3 14-3-3
However, Nrf2 is kept in an inactive state, bound to Keap1, and the complex is readily ubiquitinated and degraded.
NF- κB is present in the cytoplasm where it exists in an inactive state, bound to an inhibitory protein κB (I κB).
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CEO of Professional Science Editing for Scientists @ prosciediting.com