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That emerging reality should provide impetus to improved trial design and conduct in the future, a secondary indirect goal of our work.
34 The knowledge needed to redress the lack of compliance in these countries exists; implementation of local measures that have proven effective and improved trial registration rates elsewhere would be likely to greatly help improve compliance in these countries as well.
Further positive results from new trials with improved trial designs should encourage intensivists to incorporate new interventions into their practice.
In addition, there is only limited empirical evidence to show that improved trial similarity is associated with improved validity of indirect and mixed treatment comparison.
Certainly, the development of improved trial design that incorporates relevant and measurable outcomes favours biological agents since many of the older studies conducted on DMARDs are under-powered and suffer design flaws.
Although few black patients and other difficult-to-treat patient populations were included in the TVR phase 3 trials, an improved SVR rate was observed regardless of race, ethnicity, or level of hepatic fibrosis.
Google today quietly launched an improved always-free tier and trial program for its Cloud Platform.
A recent small phase II trial suggested an improved survival by the addition of LMWH to chemotherapy [ 33].
A potential advantage of the STEP-UP trial is an improved safety profile over the NETT and VAPOR studies.
RESPIRE, a randomized trial of an improved cookstove, was conducted in Guatemala to assess health effects of long-term reductions in wood smoke exposure.
This trial demonstrates an improved quality of life with the lower dose of cisplatin but no statistically significant survival difference between arms after application of the Bonferoni correction for multiple statistical tests.
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